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In the U.S. alone, approximately 70 million people are obese, which directly or indirectly contributes to about $100 billion in healthcare costs and 300,000 deaths annually. In the U.S., obesity as a leading cause of preventable death is exceeded only by cigarette smoking. Because it increases the risk of other chronic diseases including atherosclerosis, coronary artery disease, diabetes, sleep apnea, respiratory problems, osteoarthritis, hypercholesterolemia, and some cancers, obesity demands a continued search for effective treatment.

Currently approved anti-obesity drugs include lipase inhibitors which reduce fat absorption, such as Xenical (orlistat), anorectics or appetite suppressants, such as phentermine and Meridia (silbutramine), a serotonin and noradrenaline re-uptake inhibitor. Other medications approved for other indications used off-label for obesity include Wellbutrin (bupropion), Procyglem (diazoxide), Tenuate (diethylpropion), Glucophage (metformin), Revia (naltrexone), Bontril (phendimetrazine) and Zoloft (sertraline).

Weight loss is a common side effect of Zoloft® (sertraline hydrochloride).

On average, people lose about one to two pounds when they begin taking Zoloft.