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Weight loss is a common side effect of Zoloft® (sertraline hydrochloride). On average, people lose about one to two pounds when they begin taking Zoloft. On rare occasions, people have significant weight loss on Zoloft that requires them to stop taking the medication.

Zoloft and Weight Loss in Children
For children taking Zoloft, weight loss can also occur. On average, weight loss for children beginning Zoloft was also about one pound. However, there were a number of children taking Zoloft who experienced substantial weight loss. In fact, 7 percent of children on Zoloft saw weight loss greater than 7 percent of their body weight.

Most children and adolescents regain weight they lose on Zoloft after six to nine months of therapy; however, regular monitoring of height and weight is recommended for children and adolescents on Zoloft.

Zoloft and Weight Loss: Final
If you are noticing a weight loss with Zoloft, talk to your healthcare provider. He or she can give you other suggestions for dealing with any weight loss. If the weight loss continues, he or she may recommend adjusting the Zoloft dosage or switching to another depression medication.