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Metformin, sold under the trade name Glucophage, is used to treat diabetes mellitus (sugar diabetes) called type 2 diabetes, but recent studies show that it also helps non-diabetics to lose weight by reducing hunger.

Most obese patients are insulin resistant, and increasingly the type-2 diabetes medication metformin is being prescribed to increase glucose sensitivity and promote weight loss process.

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Phentermine is high effective diet pill which generally suits to the patients above the age of 18 years. Obese with body mass index 30 or higher than that can use Phentermine however the doctor in some cases may prescribe Phentermine for the people with body mass index 27.

Developed in the 1950's, Phentermine gained approval from the FDA in 1959 as a short term slimming aid, and has been used by thousands of dieters in the last 45 years. Useful especially for people who have difficulty in losing weight because of a sluggish metabolism, it has revolutionised the experience of dieting, turning a long and often frustrating battle into a fast and reasonably pleasant process.

In the U.S. alone, approximately 70 million people are obese, which directly or indirectly contributes to about $100 billion in healthcare costs and 300,000 deaths annually. In the U.S., obesity as a leading cause of preventable death is exceeded only by cigarette smoking. Because it increases the risk of other chronic diseases including atherosclerosis, coronary artery disease, diabetes, sleep apnea, respiratory problems, osteoarthritis, hypercholesterolemia, and some cancers, obesity demands a continued search for effective treatment.

Currently approved anti-obesity drugs include lipase inhibitors which reduce fat absorption, such as Xenical (orlistat), anorectics or appetite suppressants, such as phentermine and Meridia (silbutramine), a serotonin and noradrenaline re-uptake inhibitor. Other medications approved for other indications used off-label for obesity include Wellbutrin (bupropion), Procyglem (diazoxide), Tenuate (diethylpropion), Glucophage (metformin), Revia (naltrexone), Bontril (phendimetrazine) and Zoloft (sertraline).

Weight loss is a common side effect of Zoloft® (sertraline hydrochloride).

On average, people lose about one to two pounds when they begin taking Zoloft.